Homework 4, Survival Solution

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Description

1 Smoking (20 marks)

This task concerns the 2014 American National Youth Tobacco Survey. On the pbrown.ca/teaching/appliedstats/data page there is an R version of the 2014 dataset smoke.RData, a pdf documentation file 2014-Codebook.pdf, and the code used to create the R version of the data smokingData.R.

The age at which children first try cigarette smoking is known to be earlier for males than females, earlier in rural areas than urban areas, and to vary by ethnicity. It is likely that significant variation amongst the US states exists, and that there is variation from one school to the next.

The hypotheses to be investigated are:

  1. Geographic variation (between states) in the mean age children first try cigarettes is substantially greater than variation amongst schools. As a result, tobacco control programs should target the states with the earliest smoking ages and not concern themselves with finding particular schools where smoking is a problem.

  1. First cigarette smoking has a flat hazard function, or in other words is a first order Markov process. This means two non-smoking children have the same probability of trying cigarettes within the next month, irrespective of their ages but provided the known confounders (sex, rural/urban, etnicity) and random effects (school and state) are identical.

The collaborating scientists have provided the following prior information

  • The variability in the rate of smoking initiation between states substantial, with some states having double or triple the rate of smoking update compared other states for comparable individuals. If is a random effect for state , we might see exp( ) = 2 or 3 but unlikely to see at 10.

  • Within a given state, the ‘worst’ schools are expected to have at most 50% greater rate than the ‘healthiest’ schools or exp( ) = 1.5 for a school-level random effect is about the largest we’d see.

  • A flat hazard function is expected, so the prior on the Weibull shape parameter should allow for a 1 but it is not believed that shape parameter is 4 or 5.

Write a short consulting report addressing these hypotheses. Some additional notes:

  • Show graphs of prior and posterior densities of model parameters related to the research questions.

  • Interpret your model parameters in the context of the smoking problem, transforming model parameters to a more ‘natural’ scale as necessary.

  • It is important to state precisely what your prior distributions are (i.e. a Gamma(0.4, 3.1) distribution for the log of the intercept parameter), but also show how these distributions are consistent with the prior assumptions by showing quantiles or means or tail probabilities.

  • You’re given three confounders (sex, rural/urban, ethnicity), it’s up to you if you’d like to include interactions.

  • You might want to fit more than one model, either as exploratory work or sensitivity assessments, but you should use a single ‘best’ model to answer the research questions. Fitting two models and selecting

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one of them with a fairly ad hoc explanation is fine, comparing 10 models without some sort of formal assessment (a topic we haven’t covered) wouldn’t be.

smokeFile = Pmisc::downloadIfOld(“http://pbrown.ca/teaching/appliedstats/data/smoke.RData”)

Loading required namespace: R.utils

load(smokeFile)

smoke = smoke[smoke$Age > 9, ]

forInla = smoke[, c(“Age”, “Age_first_tried_cigt_smkg”, “Sex”, “Race”, “state”, “school”, “RuralUrban”)]

forInla = na.omit(forInla)

forInla$school = factor(forInla$school)

library(“INLA”)

forSurv = data.frame(time = (pmin(forInla$Age_first_tried_cigt_smkg, forInla$Age) 4)/10, event = forInla$Age_first_tried_cigt_smkg <= forInla$Age)

# left censoring

forSurv[forInla$Age_first_tried_cigt_smkg == 8, “event”] = 2 smokeResponse = inla.surv(forSurv$time, forSurv$event) fitS2 = inla(smokeResponse ~ RuralUrban + Sex * Race +

f(school, model = “iid”, hyper = list(prec = list(prior = “pc.prec”, param = c(0.5, 0.05)))) + f(state, model = “iid”,

hyper = list(prec = list(prior = “pc.prec”, param = c(0.5, 0.05)))), control.family = list(variant = 1,

hyper = list(alpha = list(prior = “normal”, param = c(log(4), (2/3)^(2))))), control.mode = list(theta = c(8,

2, 5), restart = TRUE), data = forInla, family = “weibullsurv”, verbose = TRUE)

rbind(fitS2$summary.fixed[, c(“mean”, “0.025quant”, “0.975quant”)], Pmisc::priorPostSd(fitS2)$summary[, c(“mean”, “0.025quant”, “0.975quant”)])

mean

0.025quant

0.975quant

(Intercept)

-0.618123774

-0.673217580 -0.562381805

RuralUrbanRural

0.114219840

0.054982509

0.173126077

SexF

-0.050079551

-0.078482659 -0.021834950

Raceblack

-0.048030138

-0.090878915 -0.005850117

Racehispanic

0.025707830

-0.008877249

0.060088014

Raceasian

-0.194755194

-0.286897781 -0.108234511

Racenative

0.110090096

0.004857814

0.207960713

Racepacific

0.175543344

0.008688396

0.324061510

SexF:Raceblack

-0.016889846

-0.073916811

0.039994596

SexF:Racehispanic

0.016228302

-0.029712823

0.062147624

SexF:Raceasian

0.005526784

-0.121718791

0.131914982

SexF:Racenative

-0.043646334

-0.200293351

0.109720191

SexF:Racepacific

-0.169554281

-0.499950675

0.123079122

SD for school

0.150218268

0.125831434

0.176461812

SD for state

0.056808074

0.024521813

0.101231683

2 Death on the roads (20 marks)

The dataset below is a subset of the data from www.gov.uk/government/statistical-data-sets/ras30-reported-casualties-in-road-accidents, with all of the road traffic accidents in the UK from 1979 to 2015. The data below

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consist of all pedestrians involved in motor vehicle accidents with either fatal or slight injuries (pedestrians with moderate injuries have been removed).

dim(pedestrians)

[1] 1159453

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pedestrians[1:3, ]

time

age

sex Casualty_Severity

Light_Conditions

54

1979-01-01 22:40:00 26 – 35

Male

Slight Darkness – lights lit

65

1979-01-02 10:40:00 26 – 35

Male

Slight

Daylight

79

1979-01-02 14:25:00 46 – 55

Male

Slight

Daylight

Weather_Conditions

54

Snowing no high winds

65

Raining no high winds

79

Raining no high winds

table(pedestrians$Casualty_Severity, pedestrians$sex)

Male Female

Slight 637977 481832

Fatal 24432 15212

range(pedestrians$time)

[1] “1979-01-01 01:00:00 EST” “2015-12-31 23:35:00 EST”

Notice that men are involved in accidents more than women, and the proportion of accidents which are fatal is higher for men than for women. This might be due in part to women being more reluctant than men to walk outdoors late at night or in poor weather, and could also reflect men being on average more likely to engage in risky behaviour than women.

Write a short report assessing whether the UK road accident data are consistent with the hypothesis that women tend to be, on average, safer as pedestrians than men, particularly as teenagers and in early adulthood. Treat fatal accidents as cases and slight injuries as controls, and use a conditional logistic regression to adjust for time of day, lighting conditions, and weather. Make your report self-contained so it can be read by someone who has not seen this homework sheet. Some (but not all) of the code below could be helpful. Explain clearly how you have stratified the data (you could use a different stratification than I did if you wish).

Fit a glm

summary(glm(y ~ sex + age + Light_Conditions + Weather_Conditions, data = x, family = “binomial”))$coef[1:4, ]

Estimate

Std. Error

z value

Pr(>|z|)

(Intercept) -3.2507678

0.02370768

-137.118754

0.000000e+00

sexFemale

-0.2988120

0.01245826

-23.985048 3.983187e-127

age0 –

5

0.1124659

0.03448000

3.261772

1.107180e-03

age6 –

10

-0.4369786

0.03241323

-13.481489

2.010085e-41

fit a conditional logistic model

library(“survival”)

theClogit = clogit(y ~ age + age:sex + strata(strata), data = x)

Some results

download data

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exp(as.matrix(theCoef[theCoef$sex==”Male”, c(“coef”, “se(coef)”)]) %*%

1 Pmisc::ciMat(02.99)) 5 10

10

20

theCoef[theCoef$sex == “Male”, “age”]

60

70

exp(as.matrix(theCoef[theCoef$sex==”Female”, c(“coef”, “se(coef)”)]) %*%

6 7 0 1 20.0.Pmisc::ciMat(0.80.9.9))1.1.1.

10

20

theCoef[theCoef$sex == “Female”, “age”]

60

70

0

30

40

50

0

30

40

50

(a) males (b) females

Figure 1: some results without adequate explanation

pedestrainFile = Pmisc::downloadIfOld(“http://pbrown.ca/teaching/appliedstats/data/pedestrians.rds”)

pedestrians = readRDS(pedestrainFile)

pedestrians = pedestrians[!is.na(pedestrians$time),

]

pedestrians$y = pedestrians$Casualty_Severity == “Fatal” pedestrians$timeCat = format(pedestrians$time, “%Y_%b_%a_h%H”) pedestrians$strata = paste(pedestrians$Light_Conditions,

pedestrians$Weather_Conditions, pedestrians$timeCat)

remove strata with no cases or no controls

theTable = table(pedestrians$strata, pedestrians$y) onlyOne = rownames(theTable)[which(theTable[, 1] ==

0 | theTable[, 2] == 0)]

x = pedestrians[!pedestrians$strata %in% onlyOne, ]

theCoef = rbind(as.data.frame(summary(theClogit)$coef), `age 26 – 35` = c(0, 1, 0, NA, NA))

theCoef$sex = c(“Male”, “Female”)[1 + grepl(“Female”, rownames(theCoef))]

theCoef$age = as.numeric(gsub(“age|Over| – [[:digit:]].*|[:].*”, “”, rownames(theCoef)))

theCoef = theCoef[order(theCoef$sex, theCoef$age),

]

matplot(theCoef[theCoef$sex == “Male”, “age”], exp(as.matrix(theCoef[theCoef$sex == “Male”, c(“coef”, “se(coef)”)]) %*% Pmisc::ciMat(0.99)),

log = “y”, type = “l”, col = “black”, lty = c(1,

2, 2), xaxs = “i”, yaxs = “i”)

matplot(theCoef[theCoef$sex == “Female”, “age”], exp(as.matrix(theCoef[theCoef$sex == “Female”, c(“coef”, “se(coef)”)]) %*% Pmisc::ciMat(0.99)),

log = “y”, type = “l”, col = “black”, lty = c(1,

2, 2), xaxs = “i”)

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